1) Which of the following is a form of spongiform encephalopathy?
2) Human beings get the human version of mad cow disease by eating infected
beef products. Which of the following is a true statement about that?
3) Prions:
4) There has never been a case of variant CJD (mad cow disease in humans)
in the United States,
5) The gene that makes the PrP (prion) protein has two alleles, which differ
by a codon for one amino acid. One codes for valine, the other for methionine.
6) The two most common neurodegenerative diseases in the elderly are:
7) Most cases of Parkinson's disease are:
8) In Parkinson's disease the primary location of degeneration in the brain is:
9) Symptoms of Parkinson's disease include:
10) The standard treatment for Parkinson's disease is the drug l-dopa.
Side effects of l-dopa include:
11) Tremor produced by purposeful movement toward a target, such as lifting
a finger to touch the nose, is called:
12) Huntington's disease is an autosomal dominant trait, which means if one
parent has it, the chance of a child inheriting it is:
13) There is no cure for Huntington's disease and it is always fatal.
14) Dementia means:
15) Multiple sclerosis:
16) The most famous person to suffer from amyotrophic lateral sclerosis
was baseball player:
17) Alzheimer's disease:
18) Aside from age, the leading risk factor for Alzheimer's disease is:
19) Neurofibrillary tangles are intracellular clumps of tau protein that occur due to
degeneration of:
20) Amyloid plaques are not unique to Alzheimer's disease but also occur in:
21) Which of the following is true of Alzheimer's disease
22) Most trials of drugs for Alzheimer's disease failed so badly that many
companies halted development of over 100 potential Alzheimer's drugs as too
expensive, too risky, and with too little hope of payoff.
23) One promising lead in Alzheimer's research is to attack tangled proteins
using a phage (a virus that normally attacks bacteria). Phages have now been
found that attack a wide variety of misfolded proteins, not only plaques and
tangles in Alzheimer's, but also the misfolded proteins that occur in Parkinson's,
ALS, and even prion diseases like CJD.
24) Lewy body dementia is associated with and sometimes occurs in:
25) Common symptoms of fronto-temporal dementia include:
26) The nigrostriatal dopamine system (tract) originates in the substantia nigra
and terminates in the:
27) Rapid, dancelike, jerky movements of the limbs on one side of the body
that the patient can't control are called:
28) Abnormal deposits of a protein called alpha-synuclein are called:
29) An infection or inflammation of brain tissue is called:
30) Which of the following statements is true of meningitis?
31) Meningitis has which of the following symptoms?
32) Probably the most common source of bacterial meningitis is:
33) Encephalitis can be transmitted by a mosquito bite.
34) Encephalitis is usually but not always viral.
35) Which of the following is a pantropic viral encephalitis?
36) Which of the following viruses lives in the trigeminal nerve ganglia and
sometimes travels up the nerve to the brain?
37) The polio virus sometimes causes:
38) This disease is a viral infection of the brain transmitted in the saliva
from the bite of an infected animal.
39) When the polio virus stays in the spinal cord and does not travel to the
brain, the disease it causes is called:
40) A leading risk factor for polio in developed countries is:
41) Iron lungs are used in the treatment of polio when the virus attacks the:
42) Depression, insomnia, delusions, hypersensitivity of the skin, alternating
periods of rage and calmness, convulsions, excessive salivation, extreme thirst, and
hydrophobia are signs of:
43) The closer to the central nervous system a rabid animal bites you, the
less time you have to get treated if the treatment is to be successful.
44) COVID-19 encephalitis is characterized by:
45) Which of the following is an example of a bacterial encephalitis?
46) Formication means:
47) Tabes dorsalis results from:
48) A patient with long-standing untreated syphilis shows the following signs: his
pupils constrict when he focuses on a nearby object, but they do not constrict when
exposed to a bright light. Which of the following is true statement about this?
49) General paresis:
50) Infection of the brain can be due to what organism in addition to a
bacterium or a virus?
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